Inverse Relationship Between Cerebrovascular Lesions and Severity of Lewy Body Pathology in Patients With Lewy Body Diseases
Identifieur interne : 001D01 ( Main/Exploration ); précédent : 001D00; suivant : 001D02Inverse Relationship Between Cerebrovascular Lesions and Severity of Lewy Body Pathology in Patients With Lewy Body Diseases
Auteurs : Estifanos Ghebremedhin [Allemagne, Australie] ; Albert Rosenberger [Allemagne] ; Udo Rüb [Allemagne] ; Mario Vuksic [Croatie] ; Tzeggai Berhe [Canada] ; Heike Bickeböller [Allemagne] ; Rob A. I. De Vos [Pays-Bas] ; Dietmar R. Thal [Allemagne] ; Thomas Deller [Allemagne]Source :
- Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Cerebrovascular pathology is a major cause of stroke and mortality. Studies on prevalence of cerebrovascular pathologies in dementia with Lewy bodies (DLBs) and Parkinson disease (PD) patients are scarce and contradictory. We aimed to determine the prevalence and severity of cerebrovascular pathologies in DLB and PD and to analyze their relationship to LB pathology. The prevalence and severity of atherosclerosis in the circle of Willis, cerebral amyloid angiopathy, cerebral infarcts, hemorrhages, small-vessel disease, white matter lesions, including the Consortium to Establish a Registry for Alzheimer Disease (CERAD) protocol as well as Braak neurofibrillary tangle stages for AD pathology were analyzed in autopsy-verified DLB (n = 13), PD (n = 102), and control subjects (n = 53). In all patient groups, the extent of LB pathology was inversely correlated to the severity of most vascular pathologies (atherosclerosis, infarcts, and small-vessel disease; all p < 0.05). By contrast, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were positively correlated with LB pathology (p < 0.05). Whereas the overall prevalence and severity of small-vessel disease, infarcts, hemorrhages, and white matter lesions were comparable among both disease groups, the extents of atherosclerosis, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were significantly higher in DLB than in those of PD patients (p < 0.05). Microinfarcts were statistically more prevalent in each patient group than in controls, whereas gross infarcts predominated in controls (p < 0.05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke.
Affiliations:
- Allemagne, Australie, Canada, Croatie, Pays-Bas
- Bade-Wurtemberg, Basse-Saxe, District de Darmstadt, District de Tübingen, Hesse (Land)
- Francfort-sur-le-Main, Göttingen, Ulm
- Université d'Ulm
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I." last="De Vos">Rob A. I. De Vos</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Laboratorium Pathologie Oost Nederland</s1><s2>Enschede</s2><s3>NLD</s3><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Laboratorium Pathologie Oost Nederland</wicri:noRegion></affiliation></author><author><name sortKey="Thal, Dietmar R" sort="Thal, Dietmar R" uniqKey="Thal D" first="Dietmar R." last="Thal">Dietmar R. 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Goethe-University</s1><s2>Frankfurt/Main</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Anatomy and Developmental Biology, School of Biomedical Sciences, the University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Laboratory of Neuropathology, Institute of Pathology, University of Ulm</s1><s2>Ulm</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Rosenberger, Albert" sort="Rosenberger, Albert" uniqKey="Rosenberger A" first="Albert" last="Rosenberger">Albert Rosenberger</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Genetic Epidemiology, Georg August-University</s1><s2>Göttingen</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Rub, Udo" sort="Rub, Udo" uniqKey="Rub U" first="Udo" last="Rüb">Udo Rüb</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute for Clinical Neuroanatomy, J.W. Goethe-University</s1><s2>Frankfurt/Main</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation></author><author><name sortKey="Vuksic, Mario" sort="Vuksic, Mario" uniqKey="Vuksic M" first="Mario" last="Vuksic">Mario Vuksic</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Croatian Institute for Brain Research, School of Medicine, University of Zagreb</s1><s2>Zagreb</s2><s3>HRV</s3><sZ>4 aut.</sZ></inist:fA14><country>Croatie</country><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Berhe, Tzeggai" sort="Berhe, Tzeggai" uniqKey="Berhe T" first="Tzeggai" last="Berhe">Tzeggai Berhe</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Queen Elizabeth II Hospital</s1><s2>Grand Prairie, Alberta</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>The Queen Elizabeth II Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Genetic Epidemiology, Georg August-University</s1><s2>Göttingen</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="De Vos, Rob A I" sort="De Vos, Rob A I" uniqKey="De Vos R" first="Rob A. I." last="De Vos">Rob A. I. De Vos</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Laboratorium Pathologie Oost Nederland</s1><s2>Enschede</s2><s3>NLD</s3><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Laboratorium Pathologie Oost Nederland</wicri:noRegion></affiliation></author><author><name sortKey="Thal, Dietmar R" sort="Thal, Dietmar R" uniqKey="Thal D" first="Dietmar R." last="Thal">Dietmar R. Thal</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Laboratory of Neuropathology, Institute of Pathology, University of Ulm</s1><s2>Ulm</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Deller, Thomas" sort="Deller, Thomas" uniqKey="Deller T" first="Thomas" last="Deller">Thomas Deller</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute for Clinical Neuroanatomy, J.W. Goethe-University</s1><s2>Frankfurt/Main</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Cerebrovascular disease</term><term>Human</term><term>Lesion</term><term>Lewy body</term><term>Lewy body dementia</term><term>Lewy body disease</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence à corps de Lewy</term><term>Pathologie cérébrovasculaire</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Lésion</term><term>Corps Lewy</term><term>Anatomopathologie</term><term>Homme</term><term>Corps Lewy maladie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cerebrovascular pathology is a major cause of stroke and mortality. Studies on prevalence of cerebrovascular pathologies in dementia with Lewy bodies (DLBs) and Parkinson disease (PD) patients are scarce and contradictory. We aimed to determine the prevalence and severity of cerebrovascular pathologies in DLB and PD and to analyze their relationship to LB pathology. The prevalence and severity of atherosclerosis in the circle of Willis, cerebral amyloid angiopathy, cerebral infarcts, hemorrhages, small-vessel disease, white matter lesions, including the Consortium to Establish a Registry for Alzheimer Disease (CERAD) protocol as well as Braak neurofibrillary tangle stages for AD pathology were analyzed in autopsy-verified DLB (n = 13), PD (n = 102), and control subjects (n = 53). In all patient groups, the extent of LB pathology was inversely correlated to the severity of most vascular pathologies (atherosclerosis, infarcts, and small-vessel disease; all p < 0.05). By contrast, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were positively correlated with LB pathology (p < 0.05). Whereas the overall prevalence and severity of small-vessel disease, infarcts, hemorrhages, and white matter lesions were comparable among both disease groups, the extents of atherosclerosis, cerebral amyloid angiopathy, CERAD, and Braak neurofibrillary tangle stages were significantly higher in DLB than in those of PD patients (p < 0.05). Microinfarcts were statistically more prevalent in each patient group than in controls, whereas gross infarcts predominated in controls (p < 0.05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Croatie</li><li>Pays-Bas</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>District de Darmstadt</li><li>District de Tübingen</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li><li>Göttingen</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Ghebremedhin, Estifanos" sort="Ghebremedhin, Estifanos" uniqKey="Ghebremedhin E" first="Estifanos" last="Ghebremedhin">Estifanos Ghebremedhin</name></region><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><name sortKey="Deller, Thomas" sort="Deller, Thomas" uniqKey="Deller T" first="Thomas" last="Deller">Thomas Deller</name><name sortKey="Ghebremedhin, Estifanos" sort="Ghebremedhin, Estifanos" uniqKey="Ghebremedhin E" first="Estifanos" last="Ghebremedhin">Estifanos Ghebremedhin</name><name sortKey="Rosenberger, Albert" sort="Rosenberger, Albert" uniqKey="Rosenberger A" first="Albert" last="Rosenberger">Albert Rosenberger</name><name sortKey="Rub, Udo" sort="Rub, Udo" uniqKey="Rub U" first="Udo" last="Rüb">Udo Rüb</name><name sortKey="Thal, Dietmar R" sort="Thal, Dietmar R" uniqKey="Thal D" first="Dietmar R." last="Thal">Dietmar R. Thal</name></country><country name="Australie"><noRegion><name sortKey="Ghebremedhin, Estifanos" sort="Ghebremedhin, Estifanos" uniqKey="Ghebremedhin E" first="Estifanos" last="Ghebremedhin">Estifanos Ghebremedhin</name></noRegion></country><country name="Croatie"><noRegion><name sortKey="Vuksic, Mario" sort="Vuksic, Mario" uniqKey="Vuksic M" first="Mario" last="Vuksic">Mario Vuksic</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Berhe, Tzeggai" sort="Berhe, Tzeggai" uniqKey="Berhe T" first="Tzeggai" last="Berhe">Tzeggai Berhe</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="De Vos, Rob A I" sort="De Vos, Rob A I" uniqKey="De Vos R" first="Rob A. I." last="De Vos">Rob A. I. De Vos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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